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  • Title: [Trial of a treatment for lymph node metastases in patients with breast cancer using aclarubicin bound to activated carbon particles].
    Author: Imanishi T, Sakakibara T, Yamazaki J, Ohyama T, Shirasu M, Tsujimoto H, Ohgaki M, Shimotsuma M, Hagiwara A, Sawai K.
    Journal: Gan To Kagaku Ryoho; 1995 Sep; 22(11):1635-7. PubMed ID: 7574780.
    Abstract:
    A new dosage formulation (ACR-CH), composed of aclarubicin (ACR) bound to fine activated carbon particles, was developed for the treatment of lymph node metastases in patients with breast cancer. In a mice experimental model, ACR-CH had superior therapeutic effects on lymph node metastases compared to the same dose of ACR aqueous solution. In clinical trials, patients with breast cancer received a local injection of 10 mg/person of ACR in the form of ACR-CH or ACR aqueous solution just before mastectomy. In the regional lymph nodes removed by the operation, the ACR concentration of 40.7 micrograms/g in patients given ACR-CH was higher than the 25.1 micrograms/g in patients given ACR aqueous solution, whereas in blood plasma the concentration was higher in patients given ACR aqueous solution than in those given ACR-CH.
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