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  • Title: [Pharmacokinetics of SK & F 104864 in experimental animals. II. Tissue distribution].
    Author: Fujita H, Okamoto M, Takao A, Abe H, Ishii R, Arase H.
    Journal: Gan To Kagaku Ryoho; 1995 Oct; 22(12):1789-92. PubMed ID: 7574811.
    Abstract:
    After intravenous bolus injection of a camptothecin derivative, SK & F 104864 (topotecan), at 20 mg/kg into Sarcoma 180 bearing mice, the tissue concentration of total topotecan (SK & F 104864 plus SK & F 105992) in the mice decreased bi-exponentially, and the beta half-lives in most tissues were longer than those in plasma. The AUCs of total topotecan were extremely large in the kidney, that was followed by the pancreas > intestine > stomach > spleen > liver > thymus > lung > tumor > uterus > plasma. The concentration of total topotecan after 24 hours decreased to less than 2% of the peak level in most tissues except the kidney.
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