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  • Title: Use of buspirone for treatment of cerebellar ataxia. An open-label study.
    Author: Lou JS, Goldfarb L, McShane L, Gatev P, Hallett M.
    Journal: Arch Neurol; 1995 Oct; 52(10):982-8. PubMed ID: 7575226.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of buspirone hydrochloride, a serotonin (5-hydroxytryptamine1A) agonist, in treating patients with cerebellar ataxia. DESIGN: Open-label study in which 20 patients (14 with cerebellar cortical atrophy and six with olivopontocerebellar atrophy) received buspirone hydrochloride, up to 60 mg/d, for 8 weeks. SETTING: Research hospital. MAIN OUTCOME MEASURES: Clinical, physiological, and psychological assessment. RESULTS: Nine patients with mild or moderate cerebellar dysfunction who completed the study showed significant improvement in clinical and self-assessment ratings, but not in a motor performance test, posturography (data were incomplete), State-Trait Anxiety Inventory, and Beck Depression Inventory. Seven patients with severe cerebellar dysfunction who completed the study had no improvement on any measure. CONCLUSIONS: Buspirone may be effective in treating mild to moderate cerebellar ataxia. A double-blind study of the efficacy of buspirone in cerebellar ataxia is warranted.
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