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  • Title: Effects on CYP27 mRNA expression in rat kidney and liver by 1 alpha, 25-dihydroxyvitamin D3, a suppressor of renal 25-hydroxyvitamin D3 1 alpha-hydroxylase activity.
    Author: Axén E, Postlind H, Wikvall K.
    Journal: Biochem Biophys Res Commun; 1995 Oct 04; 215(1):136-41. PubMed ID: 7575580.
    Abstract:
    The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats with a single i.v. dose of 1 alpha,25-dihydroxyvitamin D3 resulted in a marked suppression of CYP27 mRNA in kidney. The effects were not as pronounced as for CYP24. Liver CYP27 was not affected to the same extent. The results of the present communication indicate a coordinate regulation of CYP27 mRNA levels and 25-hydroxyvitamin D3 1 alpha-hydroxylase activity by 1 alpha,25-dihydroxyvitamin D3 in rat kidney.
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