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  • Title: Identification of a stable complex of trichosanthin with nicotinamide adenine dinucleotide phosphate.
    Author: Xiong JP, Xia ZX, Wang Y.
    Journal: J Protein Chem; 1995 Apr; 14(3):139-44. PubMed ID: 7576081.
    Abstract:
    Trichosanthin, a type I ribosome-inactivating protein with RNA N-glycosidase activity, forms a stable complex with nicotinamide adenine dinucleotide phosphate, a substrate analog. Difference UV spectroscopy, fluorescence spectroscopy, and 31P NMR are used to identify the formation of the complex, followed by a crystal structure analysis carried out to elucidate the active-site structure of trichosanthin. The determination of germinal vesicle breakdown indicates that the complex does not, at least for abortion-inducing activity, result in competitive inhibition to the protein.
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