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Title: Expression of lactococcin A and pediocin PA-1 in heterologous hosts. Author: Chikindas ML, Venema K, Ledeboer AM, Venema G, Kok J. Journal: Lett Appl Microbiol; 1995 Sep; 21(3):183-9. PubMed ID: 7576505. Abstract: Pediocin PA-1 production, immunity and secretion are specified by a cluster of four genes in Pediococcus acidilactici PAC1.0. The production by, secretion of, and immunity to lactococcin A of Lactococcus lactis are also determined by four genes. Here, expression of the pediocin operon in Lactococcus lactis is reported, which could only be achieved by placing it under control of a lactococcal promoter. Expression of the lactococcin A operon in Pediococcus is also described: recombinant clones of Pediococcus were obtained that produced and secreted both active pediocin PA-1 and lactococcin A.[Abstract] [Full Text] [Related] [New Search]