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  • Title: A family of murine NK cell receptors specific for target cell MHC class I molecules.
    Author: Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR.
    Journal: Semin Immunol; 1995 Apr; 7(2):89-101. PubMed ID: 7579199.
    Abstract:
    The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+ NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.
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