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  • Title: [The effect of pyrimidines, levamisole and prodigiozan on the antigen-specific regulation of delayed hypersensitivity in relation to the age and strain of the mice].
    Author: Gaĭnutdinova DT, Lazareva DN, Speranskiĭ VV.
    Journal: Eksp Klin Farmakol; 1995; 58(4):45-7. PubMed ID: 7580753.
    Abstract:
    The effect of pyrimidine, levamizol, and prodigiozan on the retarded hypersensitivity (RH) was studied on a model of adoptive transfer of the splenocytes from donors of different ages to young syngeneic recipients. Splenocytes from CBA and BALB/c suckers, receiving pyrimidine, activate the RH suppression. Levamizol and prodigiozan exert the same effect on BALB/c mice and inhibit the RH suppression in CBA mice. In mature CBA mice these preparations potentiate HST. The splenocytes from young and aged BALB/c donors receiving the preparations oppositely induce the RH recipients.
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