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  • Title: Stereoisomeric inversion of (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acids in rat liver peroxisome.
    Author: Ikegawa S, Goto T, Watanabe H, Goto J.
    Journal: Biol Pharm Bull; 1995 Jul; 18(7):1027-9. PubMed ID: 7581245.
    Abstract:
    The stereoisomeric inversion of (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) in rat liver peroxisome was studied. After incubation of an isomer of THCA-CoA thioester with a peroxisomal fraction, 5 beta-cholestanoic acids were extracted and optical antipodes were separated and determined by LC/APCI-MS. The transformation of (24E)-3alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid (delta 24-THCA) formed by acyl-CoA oxidase was also analyzed by GC/NICI-MS. Rapid enzymatic epimerization from either direction was observed prior to biotransformation into (24E)-delta 24-THCA.
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