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  • Title: The efficacy of lamotrigine on seizure control in 34 children, adolescents and young adults with intellectual and physical disability.
    Author: Buchanan N.
    Journal: Seizure; 1995 Sep; 4(3):233-6. PubMed ID: 7582659.
    Abstract:
    This study reports the use of lamotrigine, largely as add-on therapy, in 34 children, adolescents and adults with brain damage and resistant seizures. Seventy-four percent of the patients showed a greater than 50% improvement in seizure control with 35% becoming seizure free. This improvement in seizure control was associated with an enhanced quality of life in 65% of the patients as assessed by improved alertness, mobility, speech and independence. It was possible to reduce 36% of the pre-existing antiepileptic drugs and the side effect profile of lamotrigine was very good. It is proposed that lamotrigine may be a particularly useful antiepileptic drug in this particular group of patients.
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