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  • Title: New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity.
    Author: De Nanteuil G, Gloanec P, Lila C, Portevin B, Boudon A, Rupin A, Verbeuren TJ.
    Journal: Bioorg Med Chem; 1995 Aug; 3(8):1019-24. PubMed ID: 7582976.
    Abstract:
    Structural variations of P2 and P3 residues in tripeptidic boroarginine thrombin inhibitors led to compounds with similar potency than reference compound DuP 714, but with enhanced selectivity for thrombin compared to plasmin.
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