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  • Title: Nitro-L-arginine augments the endothelin-1 content of cerebrospinal fluid induced by cerebral ischemia.
    Author: Spatz M, Stanimirovic D, Strasser A, McCarron RM.
    Journal: Brain Res; 1995 Jun 26; 684(1):99-102. PubMed ID: 7583211.
    Abstract:
    The effect of nitro-L-arginine (NLA), inhibitor of NO synthase, on ET-1 content in cerebrospinal fluid (CSF) and on the vascular system was investigated in global ischemia/reperfusion of Mongolian gerbils. The results indicate that NLA induced a prolonged (2-3-fold) increase of ET-1 concentration above that seen in the CSF of untreated animals during ischemia/reperfusion. Both the transient and prolonged rise of ET-1 content observed in the CSF coincided with the reduction in the cerebral blood flow seen in untreated and NLA-treated gerbils, respectively, at the time of reperfusion.
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