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  • Title: Impulse-dependent and tetrodotoxin-sensitive release of GABA in the rat's substantia nigra measured by microdialysis.
    Author: Biggs CS, Fowler LJ, Whitton PS, Starr MS.
    Journal: Brain Res; 1995 Jul 03; 684(2):172-8. PubMed ID: 7583219.
    Abstract:
    gamma-Aminobutyric acid (GABA) release in the rat substantia nigra pars reticulata (SNR) was studied by microdialysis coupled with high-performance liquid chromatography and fluorimetric detection. Electrical stimulation of striatonigral axons in the internal capsule (IC) increased nigral GABA release in conscious and halothane-anaesthetized rats. This was prevented by intranigral infusion of tetrodotoxin (TTX) while basal GABA release was unaffected. Calcium-free, cobalt-containing (2 mM CoCl2) artificial cerebrospinal fluid reduced basal GABA overflow but not that evoked with high K+ (100 mM). Extracellular levels of glutamate (GLU) and taurine (TAU) were not modified by IC stimulation, TTX or 0 Ca2+ although high K+ promoted GABA and TAU release but not that of GLU. These data demonstrate an impulse-and sodium-dependent release of GABA from nigral afferent neurones which contribute little to the extracellular concentration of GABA under steady-state conditions.
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