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  • Title: Taurine prevents haloperidol-induced changes in striatal neurochemistry and behavior.
    Author: Lidsky TI, Schneider JS, Yablonsky-Alter E, Zuck LG, Banerjee SP.
    Journal: Brain Res; 1995 Jul 17; 686(1):104-6. PubMed ID: 7583261.
    Abstract:
    Repeated daily administration of haloperidol produces changes in striatal neurochemistry (decreased dopamine synthesis, upregulation of D2 receptors) and behavior (increasing catalepsy). Coadministration of taurine greatly attenuated these neuroleptic-induced changes. Possible mechanisms of taurine's mitigating effects are its attenuating influences on glutamatergic transmission and its actions as a GABAA agonist. The possibility was discussed of adding taurine to chronic antipsychotic regimens to block the side-effects typically accompanying such therapy.
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