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  • Title: Readjusting the localization of long QT syndrome gene on chromosome 11p15.
    Author: Dausse E, Denjoy I, Kahlem P, Bennaceur M, Fauré S, Weissenbach J, Coumel P, Schwartz K, Guicheney P.
    Journal: C R Acad Sci III; 1995 Aug; 318(8):879-85. PubMed ID: 7583778.
    Abstract:
    Long QT syndrome (LQT) is an autosomal dominant cardiac disease characterized by ventricular arrhythmia. A first locus for LQT has been identified on chromosome 11p15.5 (LQT1), closely linked to HRAS. To refine the location of LQT1, microsatellites were genotyped in 8 French families and the following order was determined: tel-HRAS-DRD4-D11S922-D11S4046- IGF2-INS-TH-D11S1318-D11S1323-D11S1338-D11S90 9-D11S1346-cen. By haplotype analysis, 12 crossing-over events were identified in affected and unaffected subjects, delineating the LQT1 candidate region to 7 cM. This new delineated localization between D11S1318 and D11S1323 is in a more centromeric region than previously thought and is 5 cM proximal to HRAS.
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