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  • Title: Fluorinated phenytoin anticonvulsant analogs.
    Author: Nelson WL, Kwon YG, Marshall GL, Hoover JL, Pfeffer GT.
    Journal: J Pharm Sci; 1979 Jan; 68(1):115-7. PubMed ID: 758447.
    Abstract:
    Six ring-fluorinated phenytoin analogs were synthesized, and their anticonvulsant activity in the maximal electroshock seizure and subcutaneous pentylenetetrazol assays was determined. 5-(4-Fluorophenyl)-5-phenylhydantoin, 5-(3-fluorophenyl)-5-phenylhydantoin, and 5,5-bis(4-fluorophenyl)hydantoin were active in the maximal electroshock seizure assay. The compounds were much less potent than phenytoin but showed an extremely long duration of action.
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