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  • Title: Antioxidant enzyme activities and lipid peroxidation levels in exercised and hypertensive rat tissues.
    Author: Hong H, Johnson P.
    Journal: Int J Biochem Cell Biol; 1995 Sep; 27(9):923-31. PubMed ID: 7584628.
    Abstract:
    Previous studies have shown that exercise-induced changes in muscle antioxidant status occur shortly after exercise. The present studies were designed to determine if longer-term exercise-related changes in antioxidant enzyme activities in both normotensive (WKY) and hypertensive rats (SHR) occurred, and if these changes were related to the levels of lipid peroxidation. WKY and SHR rats were exercised over a 10-week period using a progressive treadmill regimen. After a 1-week detraining period, the animals were euthanized and measurements of tissue antioxidant enzyme activities and lipid peroxide levels were determined in both exercised and cage-sedentary groups. Decreases in antioxidant activities (particularly glutathione peroxidase and catalase) in liver, kidney, skeletal and cardiac were associated with exercise training in both WKy and SHR rats (e.g. left ventricular glutathione peroxidase specific activity in WKY rats was decreased from 234 +/- 25 [SD, n = 12] to 187 +/- 17 [SD, n = 11] units/mg protein). Elevations in activities of antioxidant enzymes were generally associated with hypertension in these tissues (e.g. left ventricular glutathione peroxidase specific activity in SHR rats was 275 +/- 30 [SD, n = 12] units/mg protein), but changes in activities were more variable than those seen in response to exercise. Exercise-related changes in tissue levels of thiobarbituric acid-reactive substances (an indirect measure of tissue lipid peroxide levels) generally did not correlate with exercise-related antioxidant enzyme activity changes, and hypertension had no effect on these levels except in liver.(ABSTRACT TRUNCATED AT 250 WORDS)
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