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  • Title: Wallaby transthyretin.
    Author: Brack CM, Duan W, Hulbert AJ, Schreiber G.
    Journal: Comp Biochem Physiol B Biochem Mol Biol; 1995 Mar; 110(3):523-9. PubMed ID: 7584829.
    Abstract:
    A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site. Comparisons of nucleotide and amino acid sequences from several vertebrate species indicated that the greatest differences were in the region corresponding to the disordered N-terminus of mature human transthyretin. The evolutionary trees deduced from parsimony analyses of amino acid and nucleotide sequences of transthyretins, are consistent with that derived from fossil records.
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