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  • Title: Gentamicin-resistant Staphylococcus aureus. Emergence in an intensive care nursery.
    Author: Faden H, Neter E, McLaughlin S, Giacoia G.
    Journal: JAMA; 1979 Jan 12; 241(2):143-5. PubMed ID: 758512.
    Abstract:
    Gentamicin sulfate--resistant Staphylococcus aureus suddenly appeared in an intensive care nursery in December 1976 and became the dominant Staphylococcus; it accounted for 96% of the isolates by April 1977. All gentamicin-resistant strains were sensitive to amikacin sulfate, but 98% and 49% were resistant to kanamycin sulfate and tobramycin sulfate, respectively. All but one of the gentamicin-resistant strains were sensitive to methicillin sodium. The mechanism of gentamicin resistance appears to be plasmid mediated. Phage typing, used for epidemiologic purposes, also demonstrated that most gentamicin-resistant strains shared susceptibility to phages 29 and 52; however, 13% were completely different, indicating that gentamicin resistance is not solely related to a phage-susceptible factor.
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