These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased reproductive tract tumors in the female offspring of mice fed a high fat diet during the fetal stage of pregnancy.
    Author: Walker BE, Kurth LA.
    Journal: Cancer Lett; 1995 Oct 20; 97(1):57-60. PubMed ID: 7585478.
    Abstract:
    In a previous study, female offspring of mice consuming a high fat diet throughout pregnancy developed reproductive system tumors and tumor metastases with a frequency significantly higher than offspring of mice on a low fat diet. To test for the sensitive period more specifically, the feeding of a high fat diet was restricted to the fetal period of pregnancy in the present experiment. The offspring were raised to terminal illness and autopsied. The total number of ovarian, uterine and mammary tumors was 14 among 74 mice exposed prenatally to low fat and 34 among 75 mice exposed prenatally to high fat (P < 0.002). In mice exposed to high fat during the fetal period 13 tumors produced metastases, but no metastases were identified after exposure to low fat (P < 0.001). Thus, a maternal diet high in fat during the fetal period of pregnancy was sufficient to increase reproductive system tumors and metastases in the female offspring.
    [Abstract] [Full Text] [Related] [New Search]