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  • Title: [Biological factors and resistance to antidepressive agents].
    Author: Puech AJ, Corruble E.
    Journal: Encephale; 1995 Mar; 21 Spec No 2():17-21. PubMed ID: 7588173.
    Abstract:
    Concerning depressive disorders, biological factors remain relatively unknown. However, they might first be risk factors for depressive disorders and secondly could decrease the response to antidepressants. We studied hypothyroidism, diabetes and hypothalamic-pituitary-adrenal axis disorders. In terms of neurotransmitters, beta-adrenergic dysfunction may be involved in hypothyroidism and diabetes whereas a serotonergic dysfunction may be involved in hypothalamic-pituitary-adrenal axis disorders.
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