These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Changes in the histidine residues of Cu/Zn superoxide dismutase during aging.
    Author: Maria CS, Revilla E, Ayala A, de la Cruz CP, Machado A.
    Journal: FEBS Lett; 1995 Oct 23; 374(1):85-8. PubMed ID: 7589519.
    Abstract:
    Cu/Zn-Superoxide dismutase activity (Cu/Zn-SOD) was studied in liver from 3- and 24-month-old rat. A significant decrease of enzyme activity in liver of the aged rat was found. Various amino acid residues and protein carbonyl groups (CO) were measured in purified young and old enzyme. It was found that the 'old' enzyme had one histidine fewer and higher CO content than the 'young' Cu/Zn-SOD. Inactivation 'in vitro' of purified commercial bovine erythrocyte Cu/Zn-SOD led to a decrease in the enzymatic activity, an increase in the CO and one histidine residue modified. A similar behavior between aging and oxidation was suggested.
    [Abstract] [Full Text] [Related] [New Search]