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  • Title: In vivo rate of serotonin synthesis in brain and spinal cord of young, spontaneously hypertensive rats.
    Author: Smith ML, Browning RA, Myers JH.
    Journal: Eur J Pharmacol; 1979 Jan 15; 53(3):301-5. PubMed ID: 759207.
    Abstract:
    The accumulation of 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition was measured in hypothalamus (HYP), pons-medulla (PM) and spinal cord (SC) of 4- and 8-week-old spontaneously hypertensive (SH) and normotensive (WKY) rats. Using this method, a significant increase in the in vivo activity of tryptophan hydroxylase was observed in the PM and SC of 4-week-old, but not 8-week-old SH rats. These findings show a transient elevation in rate of 5-HT synthesis prior to the onset of hypertension, which does not appear to continue during the maintenance phase.
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