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  • Title: Pathogen antigen- and superantigen-reactive synovial fluid T cells in reactive arthritis.
    Author: Lahesmaa R, Soderberg C, Bliska J, Allsup A, Luukkainen R, Steinman L, Uchiyama T, Peltz G.
    Journal: J Infect Dis; 1995 Nov; 172(5):1290-7. PubMed ID: 7594666.
    Abstract:
    Analysis of pathogen-reactive T cell clones (CD3+4+8-TCR alpha beta +), isolated from the synovial fluid of 2 HLA-B27-positive patients with Yersinia enterocolitica-triggered reactive arthritis, has provided important information about the cellular immune response to this disease-inciting pathogen. This study demonstrates that the proteins secreted by Y. enterocolitica, including a protein with tyrosine phosphatase activity (YopH), are potent immunogens stimulating CD4+ cells within the inflamed joint. The pathogen-reactive T cell clones preferentially utilized a limited set of T cell receptor variable region gene segments. A purified Yersinia superantigen triggered a proliferative response in most of the antigen-reactive T cell clones tested. These results suggest that the activity of this pathogen's superantigen influences the cellular immune response to its antigens.
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