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  • Title: Antibodies to the nonstructural protein of parvovirus B19 in persistently infected patients: implications for pathogenesis.
    Author: von Poblotzki A, Hemauer A, Gigler A, Puchhammer-Stöckl E, Heinz FX, Pont J, Laczika K, Wolf H, Modrow S.
    Journal: J Infect Dis; 1995 Nov; 172(5):1356-9. PubMed ID: 7594677.
    Abstract:
    Three patients with persistent parvovirus B19 infection, as documented by the prolonged presence of IgM directed to the viral capsid proteins and detection of viral DNA in serum by dot-blot hybridization or polymerase chain reaction (PCR), were investigated for the presence of antibodies to the nonstructural protein NS-1 of parvovirus B19. This was done by using an ELISA based on recombinant NS-1 protein. Whereas control sera displayed no reactivity, sera from persistently infected patients showed a strong specific antibody response to NS-1. Patients were followed for 3-18 months, during which IgM titers declined but IgG directed to the nonstructural protein remained detectable. The appearance of NS-1-specific antibodies might indicate an altered course of viral infection leading to the establishment of persistently active infection and subsequent destruction of cells of nonerythroid lineage.
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