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  • Title: [The role of muscle scintigraphy with 201Tl in the morphofunctional assessment of obliterative arterial pathology of the lower limbs].
    Author: Cittanti C, Giganti M, Colamussi P, Galeotti R, Saletti A, Mannella P, Piffanelli A.
    Journal: Radiol Med; 1995 Apr; 89(4):495-500. PubMed ID: 7597232.
    Abstract:
    This study was aimed at assessing the role of stress 201Tl leg scintigraphy, compared with digital angiography, in the diagnosis and prognosis of peripheral arterial obstructive disease (PAOD) before and after surgical treatment. Fifty-four patients with known PAOD in Fontaine stages IIb, III or IV submitted to revascularization (36) or lumbar ganglionectomy (18), were examined with both angiography and scintigraphy. A statistical analysis of 360 segments (thighs and calves) was performed; in particular, correlation values were derived from 216 preoperative and 144 postoperative segments (18 patients who underwent lumbar ganglionectomy were not submitted to postoperative angiography). Scintigraphy vs. angiography sensitivity (84%), specificity (80%) and diagnostic accuracy (90%) values obtained in this study are in agreement with those reported in international literature. Scintigraphy yields information on the locoregional perfusion of an angiography-demonstrated anatomic lesion, under physiologic stress, which is particularly useful in symptomatic patients with angiographically unimportant stenoses. At present, 201Tl leg scintigraphy is the only technique yielding semiquantitative data in the assessment of single muscle groups perfusion increase in Fontaine IV patients submitted to lumbar ganglionectomy. The original contribution of this study consists in the evidence of a high predictive value (p < 0.01) of scintigraphy in the calculation of pain-free intervals in the patients with successful revascularization at clinics and angiography. This finding, if confirmed, shows a possible role for 201Tl leg scintigraphy in the diagnosis of peripheral arterial obstructive disease.
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