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  • Title: C3.SW-Soaa heterozygous congenic taster mice.
    Author: Boughter JD, Whitney G.
    Journal: Behav Genet; 1995 May; 25(3):233-7. PubMed ID: 7598666.
    Abstract:
    Sensitivity to the bitter acetylated sugar sucrose octaacetate (SOA) is mediated by a single-locus system with three alleles in mice. Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity). A congenic quartet created from taster and nontaster strains has been used to investigate the effect of the Soa locus on non-SOA aspects of taste sensitivity. In this study, we created a third congenic set, C3.SW-Soaa, from taster (SWR/J) and demitaster (C3HeB/FeJ) strains. After 11 lineal backcross generations these C3.SW mice carry the tasting allele on a 99% C3 demitaster background. After testing a total of 938 mice, taster-demitaster proportions across 12 generations were consistent with expectations from a monogenic model. The resultant three-strain congenic series will allow further examination of the mechanisms of taste.
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