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  • Title: Cap binding complexes and cellular growth control.
    Author: Mader S, Sonenberg N.
    Journal: Biochimie; 1995; 77(1-2):40-4. PubMed ID: 7599274.
    Abstract:
    The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.
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