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  • Title: Association of Helicobacter pylori and gastric autoimmunity: a population-based study.
    Author: Uibo R, Vorobjova T, Metsküla K, Kisand K, Wadström T, Kivik T.
    Journal: FEMS Immunol Med Microbiol; 1995 Mar; 11(1):65-8. PubMed ID: 7599605.
    Abstract:
    Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
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