These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clinical use of beta-lactamase inhibitors in combination with extended-spectrum penicillins.
    Author: Jones RN.
    Journal: Am J Health Syst Pharm; 1995 Mar 15; 52(6 Suppl 2):S29-33. PubMed ID: 7606587.
    Abstract:
    The in vitro antimicrobial spectrum of piperacillin-tazobactam is described and the results of clinical trials are summarized. Injectable products combining a beta-lactam antibiotic with a beta-lactamase inhibitor have a broad spectrum of activity, principally influenced by the potency of the beta-lactam. Piperacillin-tazobactam can be used for the treatment of infections caused by gram-negative, gram-positive, aerobic, and anaerobic bacteria. Appropriate indications include infections caused by mixed flora, such as gynecologic, intra-abdominal, and surgical wound infections. Other infections that appear responsive include those associated with human and animal bites, ischemic or diabetic foot infections, infected ischemic or pressure ulcers, and lower-respiratory-tract infections. Piperacillin-tazobactam has been reported to be superior to ticarcillin-clavulanate in community-acquired lower-respiratory-tract infections and superior to imipenem-cilastatin (at 1.5 g/day of imipenem) in intra-abdominal infection.
    [Abstract] [Full Text] [Related] [New Search]