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  • Title: An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice.
    Author: Gupta R, Ganguly NK, Ahuja V, Joshi K, Sharma S.
    Journal: J Med Microbiol; 1995 Jul; 43(1):33-6. PubMed ID: 7608952.
    Abstract:
    Chronic pyelonephritis was successfully produced in female BALB/c mice with Escherichia coli after introduction of the bacterial inoculum by the ascending route. E. coli strain 31-B, a nalidixic acid-resistant derivative of strain TN675 expressing type-1 pili, and E. coli strain BH-5, a mutant of 31-B, not expressing type-1 pili, were used in the model. Both the strains were able to induce chronic renal inflammation in the experimental animals. Whereas the initial colonisation was greater with strain 31-B, its non-pilate mutant BH-5 caused a significantly greater inflammatory response and also caused renal scarring observable 5 months after the infection.
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