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  • Title: Inner ear autoantibodies in patients with sensorineural hearing loss.
    Author: Kosaka K, Yamanobe S, Tomiyama S, Yagi T.
    Journal: Acta Otolaryngol Suppl; 1995; 519():176-7. PubMed ID: 7610860.
    Abstract:
    In order to identify the inner ear autoantibodies, sera of 195 patients with sensorineural hearing loss and/or vertigo were reached with bovine inner ear antigen by western blotting method. Positive reaction was seen at several molecular weights, in which 33-35 kD, 42 kD and 68 kD were highly reactive. In moderate to severe hearing loss patients, positive reactions with 33-35 kD, 42 kD, 68 kD and others were 25.8%, 26.8%, 26.8% and 71.5% respectively. On the other hand, a positive rate did not clearly correlate with diagnostic entities. Further study to purify inner ear antigen may evaluate inner ear autoimmune disease.
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