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  • Title: Clinical efficacy and toxicity of netilmicin in the treatment of gram-negative infections.
    Author: Buckwold FJ, Ronald AR, Lank B, Thompson L, Fox L, Harding GK.
    Journal: Can Med Assoc J; 1979 Jan 20; 120(2):161-7. PubMed ID: 761144.
    Abstract:
    Netilmicin, a new semisynthetic aminoglycoside antibiotic, was used to treat 41 infections in 38 patients. The outcome of four infections could not be evaluated: two patients received inadequate therapy and two did not have gram-negative infections. Clinical improvement occurred in 36 (97%) of the 37 gram-negative infections, and bacteriologic cure occurred in 30 (86%) of the 35 evaluable infections. Therapeutic serum concentrations of netilmicin were readily achieved by both intramuscular and intravenous routes. Reversible ototoxic effects occurred in 1 (3%) of 35 courses of therapy evaluated, reversible nephrotoxic effects occurred in 5 (14%) of 36 courses and mild reversible alterations in liver function occurred in 3 (19%) of 34 courses. Netilmicin appears to be effective and safe in the treatment of aerobic gram-negative infections.
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