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  • Title: [DNA ploidy pattern and p53 overexpression in gastric cancer].
    Author: Tomisaki S, Tatsuo O, Hisao O, Sakaguchi Y, Kusumoto T, Ohno S, Ichiyoshi Y, Maehara Y, Sugimachi K.
    Journal: Gan To Kagaku Ryoho; 1995 Jun; 22 Suppl 2():115-7. PubMed ID: 7611772.
    Abstract:
    DNA ploidy pattern was determined by flow cytometry and p53 overexpression was investigated immunohistochemically in 145 primary gastric cancers. Aneuploid patterns were found in 78 (65%) and diploid patterns in 67 (46%). Metastasising to lymph nodes was observed more frequently in cases with aneuploid tumors, as compared to those with diploid tumors (p < 0.01). DNA ploidy patterns were related to overexpression of p53. The incidences of overexpression of p53 in aneuploid tumors and diploid ones were 65% and 33%, respectively (p < 0.05). Thus, we suggest that gastric carcinomas with the aneuploid pattern have mutation of tumor suppressor gene p53 and high potential to metastasize to lymph nodes.
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