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  • Title: Diabetes affects alpha-crystallin chaperone function.
    Author: Cherian M, Abraham EC.
    Journal: Biochem Biophys Res Commun; 1995 Jul 06; 212(1):184-9. PubMed ID: 7612005.
    Abstract:
    In vitro glycation was previously shown to influence alpha-crystallin chaperone function. In the present study we show that this function is compromised in diabetes. The alpha H, alpha L and the total alpha fractions were isolated by gel permeation chromatography from the water-soluble protein of streptozotocin-diabetic as well as age-matched normal rats. Based on the beta L-crystallin thermal denaturation assay the chaperone function was significantly decreased in the diabetic rats.
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