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Pubmed for Handhelds

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  • Title: High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.
    Author: Rabinowicz AL, Hinton DR, Dyck P, Couldwell WT.
    Journal: Epilepsia; 1995 May; 36(5):513-5. PubMed ID: 7614929.
    Abstract:
    The incidence of seizures related to primary brain tumors is 20-80%. High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies. Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction. We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high-dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high-dose tamoxifen therapy is instituted.
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