These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Transforming growth factor-beta 1-induced expression of the mucosa-related integrin alpha E on lymphocytes is not associated with mucosa-specific homing.
    Author: Austrup F, Rebstock S, Kilshaw PJ, Hamann A.
    Journal: Eur J Immunol; 1995 Jun; 25(6):1487-91. PubMed ID: 7614974.
    Abstract:
    The integrin alpha E (HML-1, alpha IEL, alpha M290) is largely expressed on lymphocytes in epithelial sites, especially the gut mucosa. We investigated whether alpha E has any role in homing or delineates a phenotype with distinct migratory behavior. Lymph node T cells were stimulated for 5 days with anti-CD3 in the presence or absence of transforming growth factor (TGF)-beta 1 to generate alpha E+ or alpha E- cells, respectively. The two populations were then tested for their homing properties in mice. Both alpha E+ (TGF-beta-treated) and alpha E- (control) cells of either CD4+ or CD8+ subset had a low capacity to enter the gut and showed the same homing behavior with respect to a variety of other organs. The same was true for alpha E+ and alpha E- cells that had been briefly stimulated with anti-CD3 (24 h) and then allowed to return to a resting state before injection, though in this case both populations showed a greater capacity to recirculate through lymphoid tissue than was seen with fully activated cells. The results indicate that alpha E beta 7 does not act as a homing receptor, and that the expression of the site-specific marker alpha E does not correlate with a distinct homing behavior.
    [Abstract] [Full Text] [Related] [New Search]