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  • Title: Spectrophotometric investigation on complex formation of captopril with palladium(II) and its analytical application.
    Author: Jovanović T, Stanović B, Korićanac Z.
    Journal: J Pharm Biomed Anal; 1995 Mar; 13(3):213-7. PubMed ID: 7619881.
    Abstract:
    The formation of the complex between captopril and palladium(II) chloride in Britton-Robinson buffer solution was studied. It has been established that captopril reacts with palladium(II) chloride in the pH range 2.14-9.10 to form a yellow water--soluble 2:1 complex with maximum absorbance at 380 nm. By applying different spectrophotometric methods, the conditional stability constant of the complex at the optimum pH of 4.03 and ionic strength mu = 0.5 M was found to be 108.25). The molar absorptivity was 1.875 x 10(3) l mol-1 cm-1. Beer's law was obeyed in concentrations up to 5 x 10(-4) M captopril. The detection limit was 2.17 micrograms ml-1 and the relative standard deviation varied from 1.24 to 1.68%. The proposed method was found to be suitable for the accurate and reproducible analysis of captopril in water and in tablets.
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