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  • Title: Paramyxovirus induced cell fusion. Hemagglutination and hemolysis is enhanced by methylphenidate.
    Author: Aglailar Setien A, Kretschmer R, Espinosa Larios EL.
    Journal: Arch Med Res; 1995; 26(2):173-7. PubMed ID: 7620284.
    Abstract:
    The influence of methylphenidate (MP) upon cell fusion, hemagglutination and hemolysis induced by paramyxovirus was evaluated in vitro. A direct correlation between MP concentrations (range 40 mg/ml to 1.25 mg/ml) and hemagglutination and hemolysis induced by Newcastle disease virus (NDV) was found. Furthermore, MP (500 micrograms/ml) increased formation of the syncytia by LPM paramyxovirus in PK-15 cells. It is fair to speculate that MP leads to activation of the F and/or HN proteins in paramyxovirus by mechanisms other than proteolytic cleavage.
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