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  • Title: Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase.
    Author: Kikuchi M, Endo S, Inada K, Yamashita H, Takakuwa T, Nakae H, Kasai T, Baba N, Yamada Y.
    Journal: Res Commun Mol Pathol Pharmacol; 1995 Mar; 87(3):269-74. PubMed ID: 7620820.
    Abstract:
    We investigated the inhibitory effects of a protease inhibitor, FUT-175, on the production of interleukin 8 (IL-8) and polymorphonuclear leukocyte elastase (PMNE) by polymorphonuclear leukocytes (PMN) and vascular endothelial cells. IL-8 production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was inhibited by FUT-175. This compound also inhibited PMNE production by PMN following LPS stimulation.
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