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  • Title: Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue.
    Author: Iwagaki H, Hizuta A, Mori K, Yoshino T, Kawahara K, Tanaka N, Orita K.
    Journal: Res Commun Mol Pathol Pharmacol; 1995 Mar; 87(3):345-52. PubMed ID: 7620827.
    Abstract:
    We measured neopterin (NPT), an indirect marker of gamma (gamma)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous gamma-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.
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