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  • Title: Fetal wastage as a result of an alpha-fetoprotein screening programme.
    Author: Gordon YB, Grudzinskas JG, Kitau MJ, Usherwood MM, Letchworth AT, Chard T.
    Journal: Lancet; 1978 Apr 01; 1(8066):677-8. PubMed ID: 76221.
    Abstract:
    Amniocentesis was performed in 102 pregnancies in which maternal serum-alpha-fetoprotein (A.F.P.) concentrations were raised. 18 pregnancies were terminated. There were 15 neural-tube defects, 2 gastrointestinal abnormalities (1 of which could have been corrected by surgery), and 1 case of hydrocephaly. There was an association between raised maternal serum-A.F.P. and complications of late pregnancy including premature labour, perinatal death, and severe pre-eclampsia. After amniocentesis there was spontaneous abortion of 3 normal fetuses and 1 abnormal fetus.
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