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  • Title: Monoclonal antibody mediated capsular reactions (Quellung) in Cryptococcus neoformans.
    Author: Mukherjee J, Cleare W, Casadevall A.
    Journal: J Immunol Methods; 1995 Jul 17; 184(1):139-43. PubMed ID: 7622865.
    Abstract:
    Capsular reactions ('Quellung') visible by light microscopy were observed when capsule-binding monoclonal antibody (mAb) was added to Cryptococcus neoformans yeast cells. Capsular reactions were observed with capsule-binding IgM, IgG1, IgG2a, IgG2b, IgG3 and IgA mAbs. Scanning electron microscopy revealed that mAb binding produced a structural change in the fibrillar network of the capsule. The occurrence of capsular reactions with mAbs indicate that this phenomenon can be produced by the binding of antibody to a single epitope.
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