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  • Title: Contractile function of papillary muscles with carbonic anhydrase inhibitors.
    Author: Geers C, Gros G.
    Journal: Life Sci; 1995; 57(6):591-7. PubMed ID: 7623626.
    Abstract:
    Contractile parameters of directly stimulated rabbit papillary muscles were studied during incubation in baths containing the carbonic anhydrase inhibitors chlorzolamide (1*10(-3) M) or ethoxzolamide (1*10(-4) M). Both inhibitors caused an at least partly reversible decrease in isometric force as it has been observed in skeletal muscle, and--in contrast to the results in skeletal muscles--a decrease in time-to-peak and half-relaxation time. It is postulated that inhibition of the membrane-bound carbonic anhydrase of heart muscle might induce an intracellular acidosis and that this acidosis causes the observed effects on contractile parameters.
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