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  • Title: Cloning and expression of two brain-specific inwardly rectifying potassium channels.
    Author: Bredt DS, Wang TL, Cohen NA, Guggino WB, Snyder SH.
    Journal: Proc Natl Acad Sci U S A; 1995 Jul 18; 92(15):6753-7. PubMed ID: 7624316.
    Abstract:
    We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.
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