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  • Title: Inhibition of protein phosphatase 1 and 2A down-regulates beta-tubulin gene expression in Trypanosoma rhodesiense.
    Author: Li S, Donelson JE.
    Journal: Biochem Biophys Res Commun; 1995 Jul 26; 212(3):793-9. PubMed ID: 7626112.
    Abstract:
    We studied the effect of okadaic acid, a specific inhibitor of serine/threonine protein phosphatase types 1 and 2A, on the expression of beta-tubulin and procyclin genes in Trypanosoma rhodesiense. Okadaic acid was found to decrease the steady-state level of beta-tubulin mRNA about 5-fold in differentiating bloodstream trypanosomes and about 3-fold in established procyclic trypanosomes. No effect was observed on the expression of the procyclin gene. The down-regulation of beta-tubulin gene expression by okadaic acid in procyclic trypanosomes occurs at the post-transcriptional level. These results demonstrate the involvement of protein phosphatase 1 and/or 2A activity in maintaining the steady-state level of beta-tubulin mRNA in African trypanosomes.
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