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  • Title: Lipid peroxidation and superoxide dismutase activity in umbilical and maternal blood.
    Author: Stípek S, Mĕchurová A, Crkovská J, Zima T, Pláteník J.
    Journal: Biochem Mol Biol Int; 1995 Apr; 35(4):705-11. PubMed ID: 7627120.
    Abstract:
    Oxygenation of both mother and child tissues oscillate frequently during labour. We tested the lipid peroxidation caused by reactive oxygen species which are produced in consequence of tissue reoxygenation and the inactivation of these species by the maternal and newborn superoxide dismutase. Total malondialdehyde in concentrations (mean +/- SE) of 1.04 +/- 0.17, 1.57 +/- 0.22, 1.33 +/- 0.14 and 1.36 +/- 0.21 mumol/L was found in maternal plasma and red blood cells and newborn plasma and red blood cells, respectively, after uncomplicated deliveries and 4.93 +/- 1.34, 7.12 +/- 1.37, 4.77 +/- 1.29 and 7.37 +/- 1.51 mumol/L, respectively, after deliveries with clinical signs of foetal hypoxia. In newborns, erythrocyte superoxide dismutase activity reached only 82% of the maternal level (p < 0.05). The results indicate that the maternal and foetal antioxidant defence systems can be overloaded during deliveries with abnormal oxygenation, where increased lipid peroxidation occurred.
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