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  • Title: Antiviral activity of S-7HNa on the infectivity and replication of herpes simplex virus type 1 in cultured cells.
    Author: Muratore O, Pesce Schito A, Tonoli EL, Mosti L.
    Journal: J Chemother; 1995 Feb; 7(1):30-2. PubMed ID: 7629555.
    Abstract:
    The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HNa) on the infectivity and replication of herpes simplex virus type 1 in Vero cultured cells was studied. S-7HNa, at the highest concentration lacking cytotoxicity (10 mM), produced, at various inocula, a 70% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production. S-7HNa revealed a therapeutic index higher than that of the correlative ester (S-7).
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