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  • Title: [Infections in cancer patients with granulocytopenia. Retrospective studies of 59 febrile episodes with hospitalization].
    Author: Ghosn M, Dagher E, Nasr F, Chahine G, Taleb N, Nasnas R, Ghayad E.
    Journal: J Med Liban; 1994; 42(3):117-22. PubMed ID: 7629843.
    Abstract:
    A total of 59 febrile neutropenic episodes were retrospectively recorded at Hôtel-Dieu de France Hospital between August 1st 1991 and December 31st 1992. These episodes were recorded in 51 cancer patients. Median neutropenia was less than one week in 50% of the cases. The etiology of these fever was documented in 27 episodes (46%) and in 70% of the cases gram (-) rods were documented. B-Lactam and Aminoglycoside antibiotics were used in 34 episodes at the initial treatment of these patients. Success rate at this initial treatment or with a modification of the antibiotic therapy was recorded in 85% of the patients. Only 15% of the patients failed to this antibiotherapy, 2/3 of them had their disease in progression. The systemic use of Amphotericine E in those patients with prolonged febrile neutropenia and the concommitent use of growth factors in a sub-group of patients at high risk could lead to a higher success rate in these patients.
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