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  • Title: Effect of phenytoin on cortical Na(+)-K(+)-ATPase activity in global ischemic rat brain.
    Author: Imaizumi S, Kurosawa K, Kinouchi H, Yoshimoto T.
    Journal: J Neurotrauma; 1995 Apr; 12(2):231-4. PubMed ID: 7629869.
    Abstract:
    Na(+)K(+)-ATPase activity, water content, and Na+/K+ concentrations in the parietal cortex were measured in untreated and phenytoin-treated rats following global cerebral ischemia. Inhibitory effects of phenytoin treatment on brain edema and changes in Na(+)-K+ concentration with ischemia or ischemia followed by recirculation of varying intervals were assessed. The cortical Na(+)-K(+)-ATPase activity increased in the phenytoin-treated group during and after ischemia. Based on these results, we conclude that phenytoin provides ischemic brain protection by activating cortical Na(+)-K(+)-ATPase activity and by reducing intracellular Na+ and water content.
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